Down syndrome is one of the most commonly diagnosed chromosomal disorders in the UK.
DataÂ has been collected since 1989 by the National Down Syndrome Cytogenetic register (NDSRC)
- Approximate number of people living in England and Wales with Down syndrome 37,090
- Prevalence 0.66/1000
- Live birth rate in the UK Â 2012 Â 1.1/1000.
- estimated 775 Babies born with Down syndrome in England and Wales in 2012
- Risk of Down syndrome increases with maternal age
- Overall prevalence including all prenatal and postnatal diagnoses has risen since 1989 , likely to be due to both increasing maternal age , and early diagnosis of pregnancies that may be non viable
- Live birth rate has not increased since 1989
- 90% of affected pregnancies diagnosed antenatally are terminated
- Mean life expectancy in developed countries is now 60 years
- Dramatic increaseÂ from mean Â life expectancy of 12 years in 1940’s
- Morbidity and mortality remains higher than forÂ theÂ general population and for those with other intellectual disability at all ages
Presentations at DSMIG Meetings
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Wu J, Morris JK. The population prevalence of Downâ€™s syndrome in England and Wales in 2011. European Journal of Human Genetics. 2013;21(9):1016-9.
Morris JK, Springett A. The National Down Syndrome Cytogenetic Register for England and Wales: 2012 Annual Report. National Down Syndrome Cytogenic Register: Queen Mary University of London 2014
Loane M, Morris JK, Addor M-C, Arriola L, Budd J, Doray B, et al. Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe: impact of maternal age and prenatal screening. European Journal of Human Genetics. 2013;21(1):27-33.
Bittles AH, Bower C, Hussain R, Glasson EJ. The four ages of Down syndrome. The European Journal of Public Health. 2007;17(2):221-5.