Overview

• Large population based studies have shown that a wide range of solid tumours occur significantly less frequently in children and adults with Down syndrome when compared with individuals without Down syndrome
• Some solid tumours seem to be more common; these include germ cell (testicular and ovarian tumours) and retinoblastomas
• Treatment options may need to be individualised with regard to co-morbidities and communication difficulties
  • prognosis is often as good or better in people with Down Syndrome
  • people with Down syndrome may be more susceptible to complications of chemotherapy.
• Cancer prevention strategies including advice on exercise and weight control will be appropriate, and as for the general population.
• Research into the reasons for the protective effect of Down syndrome in some cancers is ongoing
• Haematological malignancies (ALL and AML) are 10-20 times more common in individuals with Down syndrome, but are very rare over the age of 30 – see Blood Disorders topic page

Presentations at DSMIG Meetings

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Last reviewed: May 28th 2020 Dr Sarah Morris, Consultant Paediatrician